![]() Dual Addiction: Pharmacological Issues in the Treatment of Concomitant Alcoholism and Drug Abuse $77.95 A highly readable and informative book that examines the neglected areas of polydrug use and alcoholism. ![]() Dacarbazine induces genotoxic and cytotoxic germ cell damage with concomitant decrease in testosterone and increase in lactate dehydrogenase concentration ... Toxicology and Environmental Mutagenesis] $10.95 This digital document is a journal article from Mut.Res.-Genetic Toxicology and Environmental Mutagenesis, published by Elsevier in 2006. The article is delivered in HTML format and is available in your Amazon.com Media Library immediately after purchase. You can view it with any web browser. Description: Treatment of cancers with cytotoxic agents such as alkylating drugs often, but not always results in transient to permanent testicular dysfunction. The present study was planned to investigate the effects of dacarbazine [5-(3,3-dimethyltriazeno) imidazole-4-carboxamide] on testicular function in mice. Swiss albino mice (9-12 weeks old) were treated with 0, 5, 25, 50, or 100mg/kg body weight/day dacarbazine (i.p.) for 5 days at intervals of 24h between treatments. Mice were sacrificed on days 7, 14, 21, 28, 35, 49, and 70 after the last treatment (6 mice/dose/sample time), and the epididymal sperm count, sperm motility, sperm morphology, testicular histopathology (qualitative histopathology, seminiferous tubular diameter and epithelial height), and intra-testicular levels of testosterone and lactate dehydrogenase were assessed. Dacarbazine decreased the body weight only on day 28 at 25mg/kg dose-level, but increased the paired testes weights at 50mg/kg on day 7, at 25-100mg/kg on day 14, and at 25 and 50mg/kg on day 21 (P ![]() International Handbook of Anger: Constituent and Concomitant Biological, Psychological, and Social Processes $199.00 From the individual rage-driven violence of domestic abuse to the destructive causes and lasting consequences of large scale ethnic and political conflict, anger and its effects are ubiquitous in human life, and are the focus of intense study across many scientific disciplines: fields as varied as affective neuroscience, health science, psychology, psychophysiology, and sociology have all contributed to recent advances in the understanding of anger. The editors of the International Handbook of Anger bring these major contributions together for a unique portrayal of the many aspects of anger?evolutionary and biological bases, behavioral processes and effects, physiological concomitants, clinical aspects, and role in the larger social picture?with coverage that is both wide-ranging and integrative. State-of-the-art findings by highly regarded experts are organized for maximum utility, with extensive cross-referencing between chapters and editors¡Ç introductory commentary linking the book¡Çs sections. A sampling of the coverage in the Handbook: Historical views and roles of anger in Western and nonwestern cultures. Current genetic, neurological, neurochemical, and psychophysiological perspectives. Cross-cultural expressions: facial, vocal, and linguistic. Affective, motivational, and cognitive processes in anger. Gender differences in anger triggers, experience, and behavior. Anger in development and across the lifespan: Infancy, childhood and adulthood Assessing anger, hostility, and anger control. Clinical aspects: psychopathology, anger and chronic pain, "Type A" behavior and cardiovascular health. Anger in family, small-group, and large-group conflict. The International Handbook of Anger presents a wealth of deep and detailed knowledge relevant to clinical and health psychology, social work, family studies, and anger management, among other fields. Its depth and breadth of coverage will make it a definitive volume informing research and practice in the years ahead. |
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