RESULTS OBTAINED

Further evaluation of the skin micronucleus test: Results obtained using 10 polycyclic aromatic hydrocarbons [An article from: Mut.Res.-Genetic Toxicology and Environmental Mutagenesis]
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This digital document is a journal article from Mut.Res.-Genetic Toxicology and Environmental Mutagenesis, published by Elsevier in . The article is delivered in HTML format and is available in your Amazon.com Media Library immediately after purchase. You can view it with any web browser.

Description:
The standard in vivo micronucleus (MN) test detects clastogenicity in hematopoietic cells and is not suitable for detecting chemicals that target the skin. Previously, we have developed an in vivo rodent skin MN test that is simple to perform and can be applied to several laboratory animals, including the hairless mouse-a species whose use simplifies the procedure of skin testing. In this paper, we report new data that confirms the predictive ability of the test. Following the application of 10 polycyclic aromatic hydrocarbons (7,12-dimethylbenz[a]anthracene; 3-methylcholanthrene; benzo[a]pyrene; dibenz[a,h]anthracene; benz[a]anthracene; dibenz[a,c]anthracene; chrysene; benzo[e]pyrene; pyrene; anthracene) with various degrees of genotoxicity to the dorsal skin of hairless mice, we found that these compounds caused MN production that in general correlated with their reported carcinogenicity. We believe that this test will be useful in detecting skin clastogens that test negative when analyzed using the standard micronucleus test.

Science and fruit growing: being an account of the results obtained at the Woburn Experimental Fruit Farm since its foundation in 1894
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Originally published 1919.: Access to the digital version of this title and other related titles can be found on CHLA (Core Historic Literature of Agriculture) at http://chla.library.cornell.edu, an electronic collection of core historical materials on US agriculture and rural life published from the mid-19th to the mid-20th century. A full list of Cornell University Library's digital collections can be found at http://www.library.cornell.edu.